For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

This item recognises rat collagen type III, a fibrillar collagen found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. This antibody shows less than 10% cross-reactivity with collagen type V and minimal reactivity with rat collagen type I and elastin.

Purified
Purified IgG - liquid

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-Col3a1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS220766 recognises rat collagen type III, a fibrillar collagen found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. This antibody shows less than 10% cross-reactivity with collagen type V and minimal reactivity with rat collagen type I and elastin.

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin, Radioimmunoassays (RIA)

Immunohistology - Frozen: Minimum Dilution: 1/250; Maximum Dilution: 1/1000;
ELISA: Minimum Dilution: 1/100; Maximum Dilution: 1/400;
Immunofluorescence: Maximum Dilution: 1/80;
Immunohistology - Paraffin: Minimum Dilution: 1/250; Maximum Dilution: 1/1000;
Radioimmunoassays: Minimum Dilution: 1/25; Maximum Dilution: 1/100

138,936 Da[Similar Products]

collagen, type III, alpha 1

collagen alpha-1(III) chain; collagen alpha-1(III) chain; procollagen, type III, alpha 1

Collagen alpha-1(III) chain

CO3A1_RAT

may be involved in craniofacial development [RGD, Feb 2006]

CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; collagen; collagen type III

Molecular Function: integrin binding; platelet-derived growth factor binding; metal ion binding; extracellular matrix structural constituent; SMAD binding

Biological Process: skin development; integrin-mediated signaling pathway; blood vessel development; collagen fibril organization; wound healing; heart development; cell-matrix adhesion; negative regulation of immune response; positive regulation of Rho protein signal transduction; response to radiation; gut development; response to mechanical stimulus; transforming growth factor beta receptor signaling pathway; response to cytokine stimulus; fibril organization and biogenesis; cerebral cortex development; peptide cross-linking; skeletal development; aging

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