Full Product Name
TLL1 Antibody, HRP conjugated
Product Synonym Names
Tolloid-like protein 1; TLL1; TLL
Product Gene Name
anti-TLL1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43897
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant human Tolloid-like protein 1 protein (522-643AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TLL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TLL1 antibody
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Applications Tested/Suitable for anti-TLL1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for TLL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001191689.1
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NCBI GenBank Nucleotide #
NM_001204760.1
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UniProt Primary Accession #
O43897
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UniProt Secondary Accession #
Q96AN3; Q9NQS4; B2RMU2[Other Products]
UniProt Related Accession #
O43897[Other Products]
Molecular Weight
44,186 Da
NCBI Official Full Name
tolloid-like protein 1 isoform 2
NCBI Official Synonym Full Names
tolloid like 1
NCBI Official Symbol
TLL1??[Similar Products]
NCBI Official Synonym Symbols
TLL; ASD6
??[Similar Products]
NCBI Protein Information
tolloid-like protein 1
UniProt Protein Name
Tolloid-like protein 1
Protein Family
Tolloid-like protein
UniProt Gene Name
TLL1??[Similar Products]
UniProt Synonym Gene Names
TLL??[Similar Products]
UniProt Entry Name
TLL1_HUMAN
NCBI Summary for TLL1
This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Comments for TLL1
TLL1: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6). A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Belongs to the peptidase M12A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q32-q33
Cellular Component: extracellular region
Molecular Function: metalloendopeptidase activity; serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; skeletal development
Disease: Atrial Septal Defect 6
Research Articles on TLL1
1. This SNP [TLL1 gene ]could not be confirmed as a risk factor for CHD [coronary heart disease]in T2DM [type-2 Diabetes mellitus]patients
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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