Anti -HLA Class 2 Antigen DQw1 (HLA DQw1 Class II, HLA-DQw1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000006.11 (32605169..32612152). Location: 6p21.3

Monoclonal

IgG2b

IIB3

Mouse

Recognizes a polymorphic determinant on DQ-like molecules which is associated with DR1, DR2 and DRw6. Reacts with a part of the DR4, DR7, DRw8 and DRw9 positive cells. The determinant is strongly expressed on DR2, DR4 and DRw6 positive cells but only weakly on DR1 and DR7 positive cells. Reacts mainly with B-lymphocytes.

Ascites
Ascites

Supplied as a liquid, sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-HLA-DQA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to HLA

Immunofluorescence (IF)

Suitable for use Immunofluorescence and Microcytotoxicity.
Dilution: Immunofluorescence: 1:10 diltuted in PBS, 1% BSA, 0.01% sodium azide.
Microcytotoxicity: 1:10 diltuted in PBS, 1% BSA, 0.01% sodium azide.

27,805 Da[Similar Products]

major histocompatibility complex, class II, DQ alpha 1

HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen; leucocyte antigen DQA1; MHC class II HLA-DQ-alpha-1; leukocyte antigen alpha chain; MHC class II surface glycoprotein; MHC class II HLA-D alpha glycoprotein; HLA class II histocompatibility antigen, DQ(W3) alpha chain

HLA class II histocompatibility antigen, DQ alpha 1 chain

DQA1_HUMAN

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

HLA-DQA1 iso4:

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; membrane; integral to plasma membrane; lysosomal membrane; plasma membrane; endosome membrane; trans-Golgi network membrane; external side of plasma membrane; MHC class II protein complex

Molecular Function: MHC class II receptor activity; peptide antigen binding

Biological Process: positive regulation of T cell differentiation; cytokine and chemokine mediated signaling pathway; T cell costimulation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; T cell receptor signaling pathway

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