Full Product Name
CD275 Polyclonal Antibody
Product Synonym Names
ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD antigen CD275; ICOSLG; B7H2; B7RP1; ICOSL; KIAA0653
Product Gene Name
anti-CD275 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75144
Purity/Purification
Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Immunogen
Synthetic peptide from human protein at AA range: 201-250
Storage Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CD275 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CD275 antibody
Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-CD275 antibody
IHC-p: 1:50-200
ELISA: 1:10000-20000
NCBI/Uniprot data below describe general gene information for CD275. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001269979.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001283050.1
[Other Products]
UniProt Primary Accession #
O75144
[Other Products]
UniProt Secondary Accession #
Q9HD18; Q9NRQ1; A8MUZ1[Other Products]
UniProt Related Accession #
O75144[Other Products]
Molecular Weight
20,120 Da
NCBI Official Full Name
ICOS ligand isoform b
NCBI Official Synonym Full Names
inducible T cell costimulator ligand
NCBI Official Symbol
ICOSLG??[Similar Products]
NCBI Official Synonym Symbols
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
??[Similar Products]
NCBI Protein Information
ICOS ligand
UniProt Protein Name
ICOS ligand
UniProt Synonym Protein Names
B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275
UniProt Gene Name
ICOSLG??[Similar Products]
UniProt Synonym Gene Names
B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1??[Similar Products]
UniProt Comments for CD275
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function ().
Research Articles on CD275
1. study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
