Rabbit Polyclonal to Human POU4F3 / BRN3C; Human POU4F3 / BRN3C; Brain-3C; POU class 4 homeobox 3; Brn-3C; DFNA15

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human POU4F3 / BRN3C

Immunoaffinity purified

PBS, 0.09% sodium azide

Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.

Small volumes of anti-POU4F3 / BRN3C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

POU4F3 Antibody, Brain-3C Antibody, BRN3C Antibody, POU class 4 homeobox 3 Antibody, Brn-3C Antibody, DFNA15 Antibody Description: POU4F3 / BRN3C is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P (2.5 ug/ml)
WB (1:1000)

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot of PO4F3 Antibody (C-term) in HL-60, MDA-MB435, CEM cell line and mouse brain,cerebellum tissue lysates (35 ug/lane).PO4F3 (arrow) was detected using the purified Pab.

37,052 Da

POU class 4 homeobox 3

POU domain, class 4, transcription factor 3

POU domain, class 4, transcription factor 3

BRN3C; Brain-3C; Brn-3C??[Similar Products]

PO4F3_HUMAN

This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]

POU4F3: May play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in POU4F3 are the cause of deafness autosomal dominant type 15 (DFNA15). DFNA15 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the POU transcription factor family. Class- 4 subfamily.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: nucleoplasm

Molecular Function: transcription factor activity

Biological Process: auditory receptor cell differentiation; axon extension; inner ear morphogenesis; neuromuscular process controlling balance; neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; retinal ganglion cell axon guidance; sensory perception of sound; transcription from RNA polymerase II promoter; vestibulocochlear nerve development; visual perception

Disease: Deafness, Autosomal Dominant 15

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