POU domain; class 4; transcription factor 3; Brain-specific homeobox/POU domain protein 3C; Brain-3C; Brn-3C; POU4F3; BRN3C

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-POU4F3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

May play a role in determining or maintaining the identities of a small subset of visual system neurons.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western blot
All lanes: POU4F3antibody at 1.97ug/ml+ Mouse brain tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 37 kDa
Observed band size: 37 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using MBS7045123 at dilution 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7045123 at dilution 1:100

37,052 Da

POU class 4 homeobox 3

POU domain, class 4, transcription factor 3

POU domain, class 4, transcription factor 3

BRN3C; Brain-3C; Brn-3C??[Similar Products]

PO4F3_HUMAN

This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]

POU4F3: May play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in POU4F3 are the cause of deafness autosomal dominant type 15 (DFNA15). DFNA15 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the POU transcription factor family. Class- 4 subfamily.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: nucleoplasm

Molecular Function: transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; visual perception

Disease: Deafness, Autosomal Dominant 15

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