P2X2; DFNA41

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

3mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-P2RX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot analysis of Mouse brain tissue using P2RX2 Polyclonal Antibody at dilution of 1:300

Immunohistochemistry of paraffin-embedded Human thyroid cancer using P2RX2 Polyclonal Antibody at dilution of 1:50

Immunohistochemistry of paraffin-embedded Human cervical cancer using P2RX2 Polyclonal Antibody at dilution of 1:50

41,370 Da

purinergic receptor P2X, ligand gated ion channel, 2

P2X purinoceptor 2; ATP receptor; P2X Receptor, subunit 2; purinergic receptor P2X, ligand-gated ion channel, 2

P2X purinoceptor 2

P2X2; P2X2??[Similar Products]

P2RX2_HUMAN

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: presynaptic membrane; cell surface; cell soma; integral to plasma membrane; postsynaptic density; apical plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex

Molecular Function: identical protein binding; copper ion binding; zinc ion binding; mercury ion binding; drug binding; ligand-gated ion channel activity; cadmium ion binding; ATP binding; nickel ion binding; purinergic nucleotide receptor activity; phosphoinositide binding; cobalt ion binding; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; protein heterooligomerization; generation of action potential; skeletal muscle fiber development; positive regulation of calcium-mediated signaling; detection of hypoxic conditions in blood by carotid body chemoreceptors; response to carbohydrate stimulus; response to ATP; behavioral response to pain; sensory perception of sound; response to hypoxia; neuromuscular synaptic transmission; neuromuscular junction development; protein homooligomerization

Disease: Deafness, Autosomal Dominant 41

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