Full Product Name
MSRB2 Antibody (Center)
Product Synonym Names
Methionine-R-sulfoxide reductase B2; mitochondrial; MsrB2; 184-; MSRB2; CBS-1; MSRB
Product Gene Name
anti-MSRB2 antibody
[Similar Products]
Antibody/Peptide Pairs
MSRB2 peptide (MBS9226464) is used for blocking the activity of MSRB2 antibody (MBS9212198)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
44-73
3D Structure
ModBase 3D Structure for Q9Y3D2
Specificity
This MSRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the Central region of human MSRB2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MSRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MSRB2 antibody
MSRB2 catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.
Product Categories/Family for anti-MSRB2 antibody
Metabolism; Signal Transduction
Applications Tested/Suitable for anti-MSRB2 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-MSRB2 antibody
WB~~1:1000
Western Blot (WB) of anti-MSRB2 antibody
Western blot analysis of MSRB2 (arrow) using rabbit polyclonal MSRB2 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MSRB2 gene.
Immunohistochemistry (IHC) of anti-MSRB2 antibody
Formalin-fixed and paraffin-embedded human hepatocarcinoma with MSRB2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Flow Cytometry (FC/FACS) of anti-MSRB2 antibody
Flow cytometric analysis of ATDC5 cells using MSRB2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
NCBI/Uniprot data below describe general gene information for MSRB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036360.3
[Other Products]
NCBI GenBank Nucleotide #
NM_012228.3
[Other Products]
UniProt Primary Accession #
Q9Y3D2
[Other Products]
UniProt Secondary Accession #
Q17R44; Q4G1C7; Q9Y5W6[Other Products]
UniProt Related Accession #
Q9Y3D2[Other Products]
NCBI Official Full Name
methionine-R-sulfoxide reductase B2, mitochondrial
NCBI Official Synonym Full Names
methionine sulfoxide reductase B2
NCBI Official Symbol
MSRB2??[Similar Products]
NCBI Official Synonym Symbols
CBS1; MSRB; PILB; CBS-1; CGI-131
??[Similar Products]
NCBI Protein Information
methionine-R-sulfoxide reductase B2, mitochondrial
UniProt Protein Name
Methionine-R-sulfoxide reductase B2, mitochondrial
Protein Family
Methionine-R-sulfoxide reductase
UniProt Gene Name
MSRB2??[Similar Products]
UniProt Synonym Gene Names
CBS-1; MSRB; MsrB2??[Similar Products]
UniProt Entry Name
MSRB2_HUMAN
UniProt Comments for MSRB2
MSRB2: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Belongs to the MsrB Met sulfoxide reductase family.
Protein type: Transcription factor; Oxidoreductase; Mitochondrial; EC 1.8.4.-
Chromosomal Location of Human Ortholog: 10p12
Cellular Component: mitochondrion
Molecular Function: zinc ion binding; peptide-methionine (R)-S-oxide reductase activity; actin binding; transcription factor activity
Biological Process: protein repair; regulation of transcription, DNA-dependent; actin filament polymerization; response to oxidative stress
Product References and Citations for anti-MSRB2 antibody
Cabreiro,F., et.al., J. Biol. Chem. 283 (24), 16673-16681 (2008)
Research Articles on MSRB2
1. the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) is a specific interaction partner of LG72.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
