Product Name
K2C1, Polyclonal Antibody
Popular Item
Full Product Name
K2C1 Antibody
Product Synonym Names
KRT1
Product Gene Name
anti-K2C1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04264
Species Reactivity
Human, Mouse
Specificity
K2C1antibody detects endogenous levels of total K2C1
Purity/Purification
Immunogen affinity purified
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human K2C1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-K2C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-K2C1 antibody
Total protein Ab
Applications Tested/Suitable for anti-K2C1 antibody
Western Blot (WB)
Application Notes for anti-K2C1 antibody
Western Blot: 1:500-1:2000
Western Blot (WB) of anti-K2C1 antibody
Western blot analysis of K2C1 expression in HEK293 cells,The lane on the left is treated with the antigen-specific peptide.
NCBI/Uniprot data below describe general gene information for K2C1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006112.3
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NCBI GenBank Nucleotide #
NM_006121.3
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UniProt Primary Accession #
P04264
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UniProt Secondary Accession #
P85925; P86104; Q14720; Q6GSJ0; Q9H298; B2RA01[Other Products]
UniProt Related Accession #
P04264[Other Products]
NCBI Official Full Name
keratin, type II cytoskeletal 1
NCBI Official Synonym Full Names
keratin 1
NCBI Official Symbol
KRT1??[Similar Products]
NCBI Official Synonym Symbols
K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK
??[Similar Products]
NCBI Protein Information
keratin, type II cytoskeletal 1
UniProt Protein Name
Keratin, type II cytoskeletal 1
UniProt Synonym Protein Names
67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1
UniProt Gene Name
KRT1??[Similar Products]
UniProt Synonym Gene Names
KRTA; CK-1; K1??[Similar Products]
UniProt Entry Name
K2C1_HUMAN
NCBI Summary for K2C1
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Comments for K2C1
K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytoskeleton; extracellular matrix; extracellular space; membrane; nucleus
Molecular Function: carbohydrate binding; protein binding
Biological Process: complement activation, lectin pathway; retinal homeostasis
Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic
Research Articles on K2C1
1. In our study, the missense mutation in the proband and his mother with epidermolytic ichthyosis was a single amino acid difference in codon 478, which causes more serious skin manifestations
Precautions
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Disclaimer
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