Product Name
Guanylate Binding Protein 1, Interferon Inducible (GBP1), Recombinant Protein
Full Product Name
Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1)
Product Synonym Names
GTP-binding protein 1; Guanine nucleotide-binding protein 1
Product Gene Name
GBP1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P32455
Purity/Purification
> 95%
Form/Format
Freeze-dried powder
Buffer Formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Source Note
Prokaryotic expression
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Subcellular Location
Cytoplasm; Golgi Apparatus Membrane; Lipid-anchor; Cytoplasmic Side; Secrete
Usage
Reconstitute in PBS or others.
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of GBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for GBP1 recombinant protein
Recombinant Protein
Applications Tested/Suitable for GBP1 recombinant protein
Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
SDS-Page of GBP1 recombinant protein
NCBI/Uniprot data below describe general gene information for GBP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002044.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002053.2
[Other Products]
UniProt Primary Accession #
P32455
[Other Products]
UniProt Secondary Accession #
Q5T8M1; D3DT26[Other Products]
UniProt Related Accession #
P32455[Other Products]
NCBI Official Full Name
guanylate-binding protein 1
NCBI Official Synonym Full Names
guanylate binding protein 1
NCBI Official Symbol
GBP1??[Similar Products]
NCBI Protein Information
guanylate-binding protein 1
UniProt Protein Name
Guanylate-binding protein 1
UniProt Synonym Protein Names
GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1
Protein Family
Guanylate-binding protein
UniProt Gene Name
GBP1??[Similar Products]
UniProt Synonym Gene Names
GBP-1; HuGBP-1??[Similar Products]
NCBI Summary for GBP1
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
UniProt Comments for GBP1
GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.
Protein type: Cell adhesion; Hydrolase; Vesicle
Chromosomal Location of Human Ortholog: 1p22.2
Cellular Component: cytosol
Molecular Function: actin binding; cytokine binding; enzyme binding; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding
Biological Process: negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling
Research Articles on GBP1
1. GBP1 expression is elevated in human Glioblastoma multiforme tumors and positively correlates with EGFRvIII status in Glioblastoma multiforme specimens, and its expression is inversely correlated with the survival rate of Glioblastoma multiforme patients. Taken together, these results reveal that GBP1 may serve as a potential therapeutic target for Glioblastoma multiforme with EGFRvIII mutation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
