Full Product Name
ARSA Antibody
Product Synonym Names
arylsulfatase A; ASA; cerebroside-sulfatase; EC 3.1.6.8; MLD
Product Gene Name
anti-ARSA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15289
Species Reactivity
Human, Mouse, Rat
Specificity
ARSA antibody detects endogenous levels of total ARSA protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human ARSA.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ARSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ARSA antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-ARSA antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ARSA antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000
Testing Data of anti-ARSA antibody
Peptide-+
Immunohistochemistry (IHC) of anti-ARSA antibody
Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using ARSA antibody. Western blot analysis of extracts from Jurkat cells and COLO cells, using ARSA antibody.
NCBI/Uniprot data below describe general gene information for ARSA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000478.3
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NCBI GenBank Nucleotide #
NM_000487.5
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UniProt Primary Accession #
P15289
[Other Products]
UniProt Secondary Accession #
Q6ICI5; Q96CJ0; B2RCA6; B7XD04; F8WCC8[Other Products]
UniProt Related Accession #
P15289[Other Products]
Molecular Weight
44,881 Da
NCBI Official Full Name
arylsulfatase A isoform a
NCBI Official Synonym Full Names
arylsulfatase A
NCBI Official Symbol
ARSA??[Similar Products]
NCBI Official Synonym Symbols
ASA; MLD
??[Similar Products]
NCBI Protein Information
arylsulfatase A
UniProt Protein Name
Arylsulfatase A
UniProt Synonym Protein Names
Cerebroside-sulfatase
Protein Family
Arylsulfatase
UniProt Gene Name
ARSA??[Similar Products]
UniProt Synonym Gene Names
ASA??[Similar Products]
NCBI Summary for ARSA
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ARSA
Hydrolyzes cerebroside sulfate.
Product References and Citations for anti-ARSA antibody
Stein C., J. Biol. Chem. 264:1252-1259(1989). Kreysing J., Eur. J. Biochem. 191:627-631(1990). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
Research Articles on ARSA
1. T]+[c.1344dupC]} in the ARSA gene, and both of the variants have been reported as disease-causing mutations previouslyfa">siblings exhibited compound heterozygous variants {[c.302G>T]+[c.1344dupC]} in the ARSA gene, and both of the variants have been reported as disease-causing mutations previouslyfa
Precautions
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Disclaimer
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