HC11; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1

For Research Use Only. Not for use in diagnostic procedures.

E Coli

>=96% as determined by SDS-PAGE and HPLC. (lot specific)

Lyophilized

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.

Small volumes of CCL2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Biological Active Protein; Immunology; Chemokine

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

8.7 kDa

C-C motif chemokine ligand 2

C-C motif chemokine 2

C-C motif chemokine 2

MCP1; SCYA2; MCAF; MCP-1??[Similar Products]

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR2 chemokine receptor binding; chemokine activity; protein kinase activity; receptor binding

Biological Process: angiogenesis; astrocyte cell migration; cell adhesion; cell surface receptor linked signal transduction; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; humoral immune response; inflammatory response; JAK-STAT cascade; lipopolysaccharide-mediated signaling pathway; macrophage chemotaxis; MAPKKK cascade; monocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ morphogenesis; positive regulation of GTPase activity; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of T cell activation; protein amino acid phosphorylation; protein kinase B signaling cascade; regulation of cell shape; viral genome replication

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Neural Tube Defects

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