DFNB36; LP2654

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody detects endogenous levels of total ESPN protein.

Antigen affinity purification

pH 7.4 PBS, 0.05% NaN3, 40% Glycerol

0.6 mg/mL (lot specific)

Store at -20 degree C.

Small volumes of anti-ESPN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement.

Total protein Ab

Immunohistochemistry (IHC)

IHC: 1:30-150

The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 47523(ESPN Antibody) at dilution 1/20.(Original magnification: 200)

The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 47523(ESPN Antibody) at dilution 1/20.(Original magnification: 200)

31,636 Da

espin

espin

Espin

DFNB36??[Similar Products]

This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009]

Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.

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