Full Product Name
ESPN, NT (Espin, Ectoplasmic Specialization Protein, Autosomal Recessive Deafness Type 36 Protein, LP2654, DFNB36)
Product Synonym Names
Anti -ESPN, NT (Espin, Ectoplasmic Specialization Protein, Autosomal Recessive Deafness Type 36 Protein, LP2654, DFNB36)
Product Gene Name
anti-ESPN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (6484836..6521004). Location: 1p36.31
3D Structure
ModBase 3D Structure for B1AK53
Specificity
Recognizes human ESPN.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the N-terminal region of human ESPN (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ESPN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ESPN antibody
ESPN is a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells.
Product Categories/Family for anti-ESPN antibody
Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-ESPN antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ESPN antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
NCBI/Uniprot data below describe general gene information for ESPN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_113663.2
[Other Products]
NCBI GenBank Nucleotide #
NM_031475.2
[Other Products]
UniProt Primary Accession #
B1AK53
[Other Products]
UniProt Secondary Accession #
Q6XYB2; Q9H0A2; Q9Y329[Other Products]
UniProt Related Accession #
B1AK53[Other Products]
Molecular Weight
91,733 Da[Similar Products]
NCBI Official Full Name
espin
NCBI Official Synonym Full Names
espin
NCBI Official Symbol
ESPN??[Similar Products]
NCBI Official Synonym Symbols
DFNB36; LP2654
??[Similar Products]
NCBI Protein Information
espin; ectoplasmic specialization protein; autosomal recessive deafness type 36 protein
UniProt Protein Name
Espin
UniProt Synonym Protein Names
Autosomal recessive deafness type 36 protein; Ectoplasmic specialization protein
UniProt Gene Name
ESPN??[Similar Products]
UniProt Synonym Gene Names
DFNB36??[Similar Products]
UniProt Entry Name
ESPN_HUMAN
NCBI Summary for ESPN
This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009]
UniProt Comments for ESPN
ESPN: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. Defects in ESPN are the cause of deafness autosomal recessive type 36 with or without vestibular involvement (DFNB36). A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; Cytoskeletal
Chromosomal Location of Human Ortholog: 1p36.31
Cellular Component: filamentous actin; stereocilium; cytoplasm; stereocilium bundle tip; brush border
Molecular Function: actin filament binding; SH3 domain binding
Biological Process: positive regulation of filopodium formation; parallel actin filament bundle formation; sensory perception of sound; locomotory behavior; negative regulation of cytoskeleton organization and biogenesis
Disease: Deafness, Autosomal Recessive 36, With Or Without Vestibular Involvement
Research Articles on ESPN
1. Flies with mutations affecting the diaphanous,forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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