HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Greater than 90% as determined by SDS-PAGE. (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Ccl2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Chotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

12.6kD

chemokine (C-C motif) ligand 2

C-C motif chemokine 2

C-C motif chemokine 2

MCP1; SCYA2; MCAF; MCP-1??[Similar Products]

CCL2_HUMAN

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: dendrite; endocytic vesicle; extracellular region; extracellular space; nerve terminal; perikaryon; perinuclear region of cytoplasm; rough endoplasmic reticulum; synapse

Molecular Function: CCR2 chemokine receptor binding; chemokine activity; heparin binding; protein kinase activity; receptor binding

Biological Process: aging; angiogenesis; astrocyte cell migration; cell adhesion; cell surface receptor linked signal transduction; cellular calcium ion homeostasis; cellular homeostasis; cellular protein metabolic process; cellular response to insulin stimulus; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; humoral immune response; inflammatory response; JAK-STAT cascade; leukocyte migration during inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPKKK cascade; maternal process involved in parturition; maternal process involved in pregnancy; monocyte chemotaxis; negative regulation of angiogenesis; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ morphogenesis; organ regeneration; positive regulation of cellular extravasation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of leukocyte mediated cytotoxicity; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of synaptic transmission; positive regulation of T cell activation; positive regulation of tumor necrosis factor production; protein amino acid phosphorylation; protein kinase B signaling cascade; regulation of cell shape; response to activity; response to amino acid stimulus; response to antibiotic; response to bacterium; response to ethanol; response to gamma radiation; response to heat; response to hypoxia; response to mechanical stimulus; response to progesterone stimulus; response to vitamin B3; response to wounding; signal transduction; transforming growth factor beta receptor signaling pathway; unfolded protein response; vascular endothelial growth factor receptor signaling pathway; viral genome replication

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Neural Tube Defects

Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)

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