MCP-1 Ccl2 Scya2 Monocyte chemotactic protein 1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

Rat

Specific for mouse C-C motif chemokine 2 denatured and native forms

>95%, Protein G Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-Ccl2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Chemotactic factor that attracts monocytes, but not neutrophils.

ELISA (EIA)

16,326 Da[Similar Products]

chemokine (C-C motif) ligand 2

C-C motif chemokine 2

C-C motif chemokine 2

Je; Mcp1; Scya2; MCP-1??[Similar Products]

CCL2_MOUSE

This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]

CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Cellular Component: cell soma; cytoplasm; dendrite; endocytic vesicle; extracellular region; extracellular space; nerve terminal; perikaryon; perinuclear region of cytoplasm; rough endoplasmic reticulum; synapse

Molecular Function: CCR2 chemokine receptor binding; chemokine activity; cytokine activity; G-protein-coupled receptor binding; heparin binding; protein binding

Biological Process: angiogenesis; cellular calcium ion homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; glial cell migration; immune response; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; macrophage chemotaxis; monocyte chemotaxis; negative regulation of angiogenesis; neutrophil chemotaxis; positive regulation of cell adhesion; positive regulation of cell-cell adhesion; positive regulation of cellular extravasation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of leukocyte mediated cytotoxicity; positive regulation of leukocyte migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of synaptic transmission; positive regulation of T cell activation; positive regulation of tumor necrosis factor production; regulation of cell shape; response to heat; response to wounding; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway

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