Rat Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) ELISA kit; RP1-172B20.4; Cav3.3; KIAA1120; calcium channel; voltage-dependent; alpha 1I subunit; calcium channel; voltage-dependent; T type; alpha 1I subunit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of CACNA1I elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9335898 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the calcium channel, voltage-dependent, T type, alpha 1I subunit (CACNA1I) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CACNA1I. The ELISA analytical biochemical technique of the MBS9335898 kit is based on CACNA1I antibody-CACNA1I antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CACNA1I antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CACNA1I. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

243,693 Da

calcium channel, voltage-dependent, T type, alpha 1I subunit

voltage-dependent T-type calcium channel subunit alpha-1I; caVT.3; voltage-dependent calcium channel; hypothetical gene supported by NM_020084; voltage-gated calcium channel subunit alpha Cav3.3; calcium channel, voltage-dependent, alpha 1I subunit; low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I)

Voltage-dependent T-type calcium channel subunit alpha-1I

CAC1I_RAT

low voltage-activated calcium channel subunit; important for calcium ion transport into nerve, muscle and endocrine cells [RGD, Feb 2006]

CACNA1I: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, calcium; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: plasma membrane; voltage-gated calcium channel complex

Molecular Function: low voltage-gated calcium channel activity

Biological Process: sperm motility; generation of action potential; sleep

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