Product Name
PD-ECGF, Polyclonal Antibody
Full Product Name
PD-ECGF Polyclonal Antibody
Product Synonym Names
TYMP; ECGF1; Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
Product Gene Name
anti-PD-ECGF antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P19971
Specificity
PD-ECGF Polyclonal Antibody detects endogenous levels of PD-ECGF protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from the N-terminal region of human PD-ECGF.
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-PD-ECGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-PD-ECGF antibody
Total protein Ab
Applications Tested/Suitable for anti-PD-ECGF antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PD-ECGF antibody
Western Blot: 1:500 - 1:2000
ELISA: 1:20000
Not yet tested in other applications.
Western Blot (WB) of anti-PD-ECGF antibody
Western Blot analysis of MCF-7, 293 cells using PD-ECGF Polyclonal Antibody.
NCBI/Uniprot data below describe general gene information for PD-ECGF. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001107227.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001113755.2
[Other Products]
UniProt Primary Accession #
P19971
[Other Products]
UniProt Secondary Accession #
Q13390; Q8WVB7; A8MW15; H9KVA0[Other Products]
UniProt Related Accession #
P19971[Other Products]
Molecular Weight
50,405 Da
NCBI Official Full Name
thymidine phosphorylase isoform 1 proprotein
NCBI Official Synonym Full Names
thymidine phosphorylase
NCBI Official Symbol
TYMP??[Similar Products]
NCBI Official Synonym Symbols
TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF
??[Similar Products]
NCBI Protein Information
thymidine phosphorylase
UniProt Protein Name
Thymidine phosphorylase
UniProt Synonym Protein Names
Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
UniProt Gene Name
TYMP??[Similar Products]
UniProt Synonym Gene Names
ECGF1; TP; PD-ECGF??[Similar Products]
UniProt Entry Name
TYPH_HUMAN
NCBI Summary for PD-ECGF
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
UniProt Comments for PD-ECGF
ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.4.2.4; Motility/polarity/chemotaxis; Cytokine; DNA replication; Transferase; Nucleotide Metabolism - pyrimidine; Phosphorylase
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol
Molecular Function: thymidine phosphorylase activity; growth factor activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity; platelet-derived growth factor receptor binding
Biological Process: mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; angiogenesis; chemotaxis; cell differentiation; DNA replication
Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type)
Research Articles on PD-ECGF
1. action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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