Full Product Name
c-Jun, phosphorylated (Thr93) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)
Product Synonym Names
Anti -c-Jun, phosphorylated (Thr93) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)
Product Gene Name
anti-C-JUN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_010448.2 (141029845..141031055)
3D Structure
ModBase 3D Structure for P56432
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human c-Jun when phosphorylated at threonine 93. Species Cross-Reactivity: mouse, rat.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Immunogen
Synthetic phosphopeptide corresponding to human c-Jun around the phosphorylation site of threonine 93 (T-P-TP-P-T).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-C-JUN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C-JUN antibody
The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 . AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Product Categories/Family for anti-C-JUN antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-C-JUN antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-C-JUN antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:500-1:1,000
Immunohistochemistry: 1:50-1:100
NCBI/Uniprot data below describe general gene information for C-JUN. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P56432
[Other Products]
UniProt Related Accession #
P56432[Other Products]
Molecular Weight
35,629 Da[Similar Products]
NCBI Official Full Name
c-Jun
NCBI Official Symbol
C-JUN??[Similar Products]
NCBI Official Synonym Symbols
Jun
??[Similar Products]
NCBI Protein Information
transcription factor AP-1; AP1; activator protein 1; proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog
UniProt Protein Name
Transcription factor AP-1
UniProt Synonym Protein Names
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog
Protein Family
C-Jun-amino-terminal kinase-interacting protein
UniProt Gene Name
JUN??[Similar Products]
UniProt Entry Name
JUN_PIG
UniProt Comments for C-JUN
Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
Subunit structure: Heterodimer with either FOS or BATF3 or ATF7
By similarity. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex
By similarity. Interacts with RNF187
Subcellular location: Nucleus
Post-translational modification: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC
Sequence similarities: Belongs to the bZIP family. Jun subfamily.Contains 1 bZIP domain.
Precautions
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