Product Name
CEP152, cDNA Clone
Full Product Name
CEP152 cDNA Clone
Product Gene Name
CEP152 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtcattag actttggcag tgtggcacta ccagtgcaaa atgaagatga agagtatgac gaagaggact atgaaagaga gaaagagttg cagcagttac tcacagacct tccccatgac atgctggatg acgacctctc ctctccagag ctccagtatt cggactgcag cgaggatggc acagacggac aaccacatca tcctgagcaa ttggagatga gctggaatga gcaaatgctg cccaaatctc aaagtgtaaa tggctataat gaaattcaga gtttatatgc tggagaaaaa tgtggtaatg tctgggaaga aaatagaagt aaaactgaag accgacatcc tgtgtaccat cctgaagaag gtggagatga aggtggaagt ggttatagtc ctccaagtaa atgtgaacag actgatttat atcaccttcc tgaaaacttt aggccatata ccaatggtca gaagcaggaa tttaataacc aagcaaccaa tgtaattaaa ttttcagatc ctcaatggaa ccattttcag ggtcccagtt gtcaaggttt ggaaccgtat aataaagtga catataaacc ttatcagtct tctgcccaga ataatggctc accagcccag gagataacag gaagtgacac attcgaaggc ctgcaacaac aatttttagg agctaatgag aactctgcag aaaatatgca gattattcaa cttcaggttc ttaacaaagc aaaagagaga caactggaga acttaattga aaagttaaat gaaagtgaac gtcaaattcg atatctgaat caccagcttg taataataaa agatgaaaag gatggtttga ctctcagcct tcgagaatca cagaaactct ttcagaatgg aaaagaaaga gagatacagc ttgaagctca aataaaagca ctggagactc agatacaagc attaaaagtc aatgaagaac agatgatcaa gaagtccaga acaactgaaa tggctctgga aagcttgaag cagcagctgg tggaccttca tcattctgaa tcacttcaac gagctagaga acagcatgag agcattgtta tgggcctcac aaagaagtac gaagagcaag tattgtcctt acaaaagaat ttggatgcca cagtcaccgc acttaaagaa caggaagaca tttgctctcg tctgaaagat cacgtgaaac aactggaaag gaatcaagaa gcaatcaagt tagaaaagac tgagatcatt aataagttga caagaagtct agaggagagt caaaagcagt gtgcccactt gttgcagtcc gggtcagtac aagaggtggc tcagctacag ttccagctgc agcaagcaca gaaggcacat gctatgagtg caaacatgaa caaggctttg caagaagaat taacagaact aaaagatgaa atttctctct atgaatctgc tgcaaaacta ggaatacatc caagtgactc agaaggagaa ttaaatatag aactcactga atcgtatgtg gatttgggta ttaaaaaggt caactggaaa aaatccaaag ttaccagcat tgtacaagaa gaagacccaa atgaagagct ttcaaaagat gagttcattc tgaagttaaa ggcagaagta cagcgtttgc tgggtagcaa ctcaatgaag cgtcatctgg tgtctcagtt acaaaatgac ctcaaagact gtcataagaa aattgaagat ctccaccaag tgaagaagga tgaaaaaagc attgaggttg agactaaaac agatacctca gaaaaaccaa agaatcaatt atggcctgag tcttctactt ctgatgttgt cagagatgat attctgctgc ttaaaaatga aattcaagtt ttacaacaac aaaatcagga acttaaagaa actgaaggaa aactgagaaa tacaaatcaa gacttatgta atcaaatgag acaaatggta caagattttg accatgacaa acaagaagct gtggataggt gtgaaaggac ttatcagcag caccatgaag ccatgaaaac tcaaatacgt gaaagcctat tagcaaagca tgctttggag aagcagcagc tctttgaggc ttatgagaga actcatttgc aactgaggtc tgagttggat aagttgaata aggaggtgac tgctgtgcag gaatgttacc tagaagtgtg cagagagaag gataatctag aattgactct caggaagacc actgaaaagg agcaacagac tcaggagaag atcaaagaaa aactcattca acagcttgaa aaggagtggc agtctaagct ggatcaaact ataaaggcaa tgaaaaagaa gaccttagat tgtggcagcc aaactgacca agtaaccacc agtgatgtta tttccaagaa agagatggca attatgatag aagagcagaa gtgcacaatc cagcaaaact tagaacaaga gaaggacata gccatcaagg gggctatgaa gaaactcgaa attgaattgg aactcaaaca ttgtgaaaat attaccaaac aggtagaaat agctgtgcaa aatgctcatc agcgatggct gggagaacta ccagagctgg cagagtatca agcacttgtg aaggcagaac agaaaaagtg ggaagaacag catgaggtct ctgtgaacaa aaggatatca tttgctgttt ctgaagctaa agagaaatgg aagagtgagc ttgaaaatat gaggaaaaat atacttcctg gaaaggaatt ggaagagaag attcattctc ttcagaagga acttgagtta aagaacgaag aagtccctgt ggtcatcagg gctgagttag ctaaggctcg gagtgaatgg aacaaagaaa agcaagaaga aatccacaga atccaagaac aaaatgagca agattaccgg caatttttag atgatcaccg aaataaaatt aatgaggtgc ttgcggcagc taaagaagac tttatgaaac aaaaaactga actacttctt cagaaggaga cagaattaca aacttgtcta gaccagagtc gtagagaatg gactatgcag gaagccaagc ggatccaact ggaaatctat cagtatgagg aagacatcct gactgtactt ggggttcttt taagtgatac ccaaaaggag cacatcagtg attctgagga caagcagctt ttggaaatca tgtcgacttg ttcttcaaaa tggatgtctg tgcaatattt tgaaaaacta aagggctgca tacagaaagc atttcaagat acacttcctc tgcttgtaga aaacgctgac ccagaatgga aaaagagaaa tatggccgag ctctctaagg attctgccag ccagggcact ggccaaggag accctggacc tgctgctgga caccatgctc agcccttggc cttacaagca acagaagcag aagctgaaga gaataataaa gttgttgaag aattaataga agaaaacaac gacatgaaga ataaattgga agaattgcaa acactttgta aaacaccacc aaggtcattg tcagcagggg ccattgaaaa tgcttgcctg ccatgcagtg ggggagcctt ggaagaactt cgtgggcagt acattaaagc tgtaaaaaaa attaaatgtg acatgcttcg ttatattcag gagagtaagg aacgagctgc agaaatggta aaagcagagg tactgcgaga acgtcaagaa accgcccgaa agatgcgcaa atattatttg atttgcctcc aacagatttt gcaggatgat ggaaaagaag gggctgagaa aaagattatg aatgctgcta gcaaacttgc tacaatggca aaattactgg aaacacctat ttctagtaag tcccaaagca aaactacaca gtcagcactg cccctaactt cagagatgct gattgcagtt aaaaaatcaa aaagaaatga tgtgaatcag aaaataccat gttgtattga aagcaaatca aatagtgtaa acaccatcac cagaactctg tgcgaacaag ctcccaagag gagggcagct tgtaacttac aaaggctgtt agagaactca gagcatcaga gcataaagca tgtgggatcc aaagagacac atttggaatt ccagtttggg gatggtagtt gcaagcacct aaacagtttg ccaaggaatg tttctcctga gtttgttcct tgtgaaggtg aaggaggctt tggtttgcac aagaagaaag acctactcag tgataatggt tctgaatcac ttccgcattc agctgcatac ccctttcttg gaaccttagg aaataaaccc tcacctagat gtacccctgg tccttctgaa tcaggatgca tgcatataac ctttcgcgat tctaatgaaa gacttggttt aaaagtatat aaatgcaatc cactaatgga aagtgaaaat gctgcatctg agaaaagtca aggtttggat gttcaggaac ctccagtaaa agatggaggg gaccttagtg actgcttggg ctggccttcc agcagtgcaa ccttatcctt tgacagtcgt gaagcatcat ttgtacatgg taggccacaa ggaactttgg aaataccaag tgaatctgtt aaatccaaac agttttcacc atccggttat ctttcagata cagaggaaag taatatgatt tgtcaaacaa tgaaatgtca gcgttatcaa actccatacc tgtcagaaga aaccacgtat ttggagccag gaaagatcag tgtgaattgt ggacacccat ctcgtcataa ggctgataga ttaaagtcag atttcaaaaa actgagcagt acattaccat cttcagtgtg tcagcagcct tcaagaaaat taattgttcc gctatctagc caacaagata gtggctttga tagcccattt gttaatctag actaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CEP152 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CEP152. It may not necessarily be applicable to this product.
NCBI Accession #
BC117182
[Other Products]
UniProt Secondary Accession #
Q17RV1; Q6NTA0; E7ER66[Other Products]
UniProt Related Accession #
O94986[Other Products]
Molecular Weight
189,071 Da
NCBI Official Full Name
Homo sapiens centrosomal protein 152kDa, mRNA
NCBI Official Synonym Full Names
centrosomal protein 152
NCBI Official Symbol
CEP152??[Similar Products]
NCBI Official Synonym Symbols
MCPH4; MCPH9; SCKL5
??[Similar Products]
NCBI Protein Information
centrosomal protein of 152 kDa
UniProt Protein Name
Centrosomal protein of 152 kDa
Protein Family
Centrosomal protein
UniProt Gene Name
CEP152??[Similar Products]
UniProt Synonym Gene Names
KIAA0912; Cep152??[Similar Products]
UniProt Entry Name
CE152_HUMAN
NCBI Summary for CEP152
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
UniProt Comments for CEP152
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
Research Articles on CEP152
1. Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer.
Precautions
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Disclaimer
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