Product Name
5-Lipoxygenase (5-LOX), Polyclonal Antibody
Full Product Name
Phospho-5-Lipoxygenase (Ser272) Antibody
Product Synonym Names
5 LO; 5 LOX; 5-lipoxygenase; 5-LO; 5LOX; 5LPG; ALOX 5; Alox5; Arachidonate 5 lipoxygenase; Arachidonate 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; Arachidonic acid 5 lipoxygenase; Leukotriene A4 synthase; LOG 5; LOG5; LOX5_HUMAN; MGC163204
Product Gene Name
anti-5-LOX antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P09917
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
Immunogen
A synthesized peptide derived from human 5-Lipoxygenase around the phosphorylation site of Ser272
Storage Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-5-LOX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-5-LOX antibody
Western Blot (WB)
Application Notes for anti-5-LOX antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for 5-LOX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000689.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000698.4
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UniProt Primary Accession #
P09917
[Other Products]
UniProt Secondary Accession #
Q5JQ14; B7ZLS0; E5FPY5; E5FPY7; E5FPY8[Other Products]
UniProt Related Accession #
P09917[Other Products]
NCBI Official Full Name
arachidonate 5-lipoxygenase isoform 1
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase
NCBI Official Symbol
ALOX5??[Similar Products]
NCBI Official Synonym Symbols
5-LO; 5LPG; LOG5; 5-LOX
??[Similar Products]
NCBI Protein Information
arachidonate 5-lipoxygenase
UniProt Protein Name
Arachidonate 5-lipoxygenase
UniProt Gene Name
ALOX5??[Similar Products]
UniProt Synonym Gene Names
LOG5; 5-LO; 5-lipoxygenase??[Similar Products]
NCBI Summary for 5-LOX
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for 5-LOX
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Research Articles on 5-LOX
1. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.
Precautions
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Disclaimer
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