2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase; OGDH; 1.2.4.2

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of OGDH elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2881231 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 2-oxoglutarate dehydrogenase, mitochondrial (OGDH) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing OGDH. The ELISA analytical biochemical technique of the MBS2881231 kit is based on OGDH antibody-OGDH antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect OGDH antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, OGDH. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

48,180 Da

oxoglutarate dehydrogenase

2-oxoglutarate dehydrogenase, mitochondrial

2-oxoglutarate dehydrogenase, mitochondrial

OGDC-E1??[Similar Products]

ODO1_HUMAN

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

OGDH: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.2.4.2; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 7p14-p13

Cellular Component: cytosol; mitochondrial matrix; mitochondrial membrane; mitochondrion; oxoglutarate dehydrogenase complex

Molecular Function: chaperone binding; heat shock protein binding; metal ion binding; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamin pyrophosphate binding

Biological Process: 2-oxoglutarate metabolic process; cellular metabolic process; cerebellar cortex development; generation of precursor metabolites and energy; glycolysis; glyoxylate metabolic process; hippocampus development; lysine catabolic process; NADH metabolic process; pyramidal neuron development; striatum development; succinyl-CoA metabolic process; tangential migration from the subventricular zone to the olfactory bulb; thalamus development; tricarboxylic acid cycle

Disease: Alpha-ketoglutarate Dehydrogenase Deficiency

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