Hxt; Thing1; eHand; bHLHa27; Class A basic helix-loop-helix protein 27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against HAND1. It has been selected for its ability to recognize HAND1 in immunohistochemical staining and western blotting.

Affinity Chromatography

Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-HAND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot: Sample: Recombinant protein.

DAB staining on fromalin fixed paraffin- embedded Kidney tissue)

23,806 Da

heart and neural crest derivatives expressed 1

heart- and neural crest derivatives-expressed protein 1

Heart- and neural crest derivatives-expressed protein 1

Ehand; Hxt; Thing1; eHAND; Th1??[Similar Products]

HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the *****, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box).

Protein type: Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor

Chromosomal Location of Human Ortholog: 11 B1.3|11 35.27 cM

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: bHLH transcription factor binding; DNA binding; enzyme binding; identical protein binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding

Biological Process: angiogenesis; cell differentiation; cell fate determination; embryonic heart tube development; heart development; heart looping; heart morphogenesis; in utero embryonic development; mesoderm formation; multicellular organism development; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac muscle tissue morphogenesis

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