For Research Use Only. Not for use in diagnostic procedures.

Store at -20 degree C for 12 months.

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Background/Introduction: 5-Lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase that converts unsaturated fatty acids to epoxides; for example the synthesis of leukotrienes from arachidonic acid. It is involved in processes like cell proliferation, differentiation and inflammation and has been implicated in inflammation and hyper proliferation mediated diseases like asthma, rheumatoid arthritis and cancer. Research for identifying potential remedies for such diseases involves the identification of inhibitors of 5-lipoxygenase.5-Lipoxygenase Inhibitor Screening Kit uses Zileuton, a well-known 5-lipoxygenase inhibitor as positive control, and provides a simple and fast method to screen/ characterize potential 5-lipoxygenase inhibitors.

Fatty Acid Metabolism

Screening of potential inhibitors of 5-lipoxygenase

56,291 Da[Similar Products]

arachidonate 5-lipoxygenase

arachidonate 5-lipoxygenase

Arachidonate 5-lipoxygenase

LOG5; 5-LO; 5-lipoxygenase??[Similar Products]

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.

Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q11.21

Cellular Component: cytosol; extracellular region; extracellular space; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm

Molecular Function: arachidonate 5-lipoxygenase activity; iron ion binding; protein binding

Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway; neutrophil degranulation

Disease: Asthma, Susceptibility To

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