Product Name
Forkhead box protein C1-A (foxc1-a), Recombinant Protein
Full Product Name
Recombinant Xenopus laevis Forkhead box protein C1-A (foxc1-a)
Product Gene Name
foxc1-a recombinant protein
[Similar Products]
Product Synonym Gene Name
foxc1-a[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-492aa, full length protein
Sequence
MQARYSVSSP NSLGVVPYLS GEQSYYRAAA AAAAAGGGYT GMAAPMSMYS HPAHEQYQAG MARAYGPYTP QPQPKDMVKP PYSYIALITM AIQNAPDKKI TLNGIYQFIM ERFPFYRDNK QGWQNSIRHN LSLNECFVKV PRDDKKPGKG SYWTLDPDSY NMFENGSFLR RRRRFKKKDV SKDATKEDKE RLLKEHHGSQ SAAAQQQRQQ QQSQAQAEQD SNSQPVRIQD IKTENGTSSP PQSMSPALSA VPKIESPDSS SSMSSGSPHS IPSNRSMSLE AAESHHPHHQ QHSQGFSVDN IMTSLRGSPQ GSAELPSPLI SSSRTGIAPS LSLSYSPGQG SIYSSPCSQG TSSGGGAGTY HCNMQAMSLY SGDRSGHLTP ANTPAATTVE ETLPDYSIST TSAQSHGNQE HPHQGRLPSW YLNQTGELGH LAGATYPGQQ QNFHSVREMF ESQRLALNSS PVNGNSSCQM SFPPSQSLYR TSGAFVYDCS KF
3D Structure
ModBase 3D Structure for Q9PVZ3
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Xenopus laevis (African clawed frog)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of foxc1-a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for foxc1-a. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001080937.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001087468.1
[Other Products]
UniProt Primary Accession #
Q9PVZ3
[Other Products]
UniProt Secondary Accession #
Q9YHB2; B7ZQ99; B7ZQA1; B7ZRK5[Other Products]
Molecular Weight
53,674 Da
NCBI Official Full Name
winged helix transcription factor XFD-11
NCBI Official Symbol
foxc1-A??[Similar Products]
NCBI Official Synonym Symbols
XFD-11
??[Similar Products]
NCBI Protein Information
winged helix transcription factor XFD-11
UniProt Protein Name
Forkhead box protein C1-A
UniProt Synonym Protein Names
Fork head domain-related protein 11
Protein Family
Forkhead box protein
UniProt Gene Name
foxc1-a??[Similar Products]
UniProt Synonym Gene Names
foxc1; XFD-11??[Similar Products]
UniProt Comments for foxc1-a
DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (). Plays a role at the gastrula stage for expression of several mesodermal and endodermal genes (PubMed:17705306). At the late neurula stage, regulates expression of adhesion genes to maintain cell adhesion in the mesodermal germ layer (PubMed:17705306).
Research Articles on foxc1-a
1. at late neurula to early tailbud stage, FoxC1 depletion causes down-regulation of adhesion molecules, EP & E cadherin, & members of the Ephrin/EphR signaling families in the mesoderm germ layer resulting in loss of adhesion & apoptosis of mesodermal cells
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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