Product Name
CBLC, Blocking Peptide
Full Product Name
CBLC Peptide - C-terminal region
Product Gene Name
CBLC blocking peptide
[Similar Products]
Product Synonym Gene Name
CBL-3; RNF57; CBL-SL[Similar Products]
CBLC peptide (MBS3248106) is used for blocking the activity of CBLC antibody (MBS3223473)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: SIYQFHGQAT AEDSGNSSDQ EGRELELGQV PLSAPPLPPR PDLPPRKPRN
3D Structure
ModBase 3D Structure for Q9ULV8
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of CBLC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CBLC blocking peptide
This is a synthetic peptide designed for use in combination with anti- CBLC Antibody, made
Target Description: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Product Categories/Family for CBLC blocking peptide
Peptide
NCBI/Uniprot data below describe general gene information for CBLC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001124324.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001130852.1
[Other Products]
UniProt Primary Accession #
Q9ULV8
[Other Products]
UniProt Related Accession #
Q9ULV8[Other Products]
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL-C isoform 2
NCBI Official Synonym Full Names
Cbl proto-oncogene C
NCBI Official Symbol
CBLC??[Similar Products]
NCBI Official Synonym Symbols
CBL-3; RNF57; CBL-SL
??[Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase CBL-C
UniProt Protein Name
E3 ubiquitin-protein ligase CBL-C
UniProt Synonym Protein Names
RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
CBLC??[Similar Products]
UniProt Synonym Gene Names
CBL3; RNF57??[Similar Products]
UniProt Entry Name
CBLC_HUMAN
NCBI Summary for CBLC
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for CBLC
Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleus
Molecular Function: signal transducer activity; phosphotyrosine binding; zinc ion binding; calcium ion binding; SH3 domain binding; ligase activity; epidermal growth factor receptor binding
Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination
Research Articles on CBLC
1. Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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