Product Name
5 Lipoxygenase (5-LOX), Polyclonal Antibody
Full Product Name
Anti-5 Lipoxygenase Rabbit pAb
Product Gene Name
anti-5-LOX antibody
[Similar Products]
Product Synonym Gene Name
5-LO; 5LPG; LOG5; MGC163204[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P09917
Species Reactivity
Human, Mouse, Rat
Specificity
5 Lipoxygenase Antibody detects endogenous levels of total 5 Lipoxygenase
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human 5 Lipoxygenase
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-5-LOX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-5-LOX antibody
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Applications Tested/Suitable for anti-5-LOX antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-5-LOX antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
FC/FACS: 1:50
Western Blot (WB) of anti-5-LOX antibody
Western blot analysis of 5 Lipoxygenase expression in K562 cell lysate.
NCBI/Uniprot data below describe general gene information for 5-LOX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000689.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000698.4
[Other Products]
UniProt Primary Accession #
P09917
[Other Products]
UniProt Secondary Accession #
Q5JQ14; B7ZLS0; E5FPY5; E5FPY7; E5FPY8[Other Products]
UniProt Related Accession #
P09917[Other Products]
NCBI Official Full Name
arachidonate 5-lipoxygenase isoform 1
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase
NCBI Official Symbol
ALOX5??[Similar Products]
NCBI Official Synonym Symbols
5-LO; 5LPG; LOG5; 5-LOX
??[Similar Products]
NCBI Protein Information
arachidonate 5-lipoxygenase
UniProt Protein Name
Arachidonate 5-lipoxygenase
UniProt Gene Name
ALOX5??[Similar Products]
UniProt Synonym Gene Names
LOG5; 5-LO; 5-lipoxygenase??[Similar Products]
NCBI Summary for 5-LOX
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for 5-LOX
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Research Articles on 5-LOX
1. The knockdown of arachidonate 5-lipoxygenase (Alox5) gene can induce the decreased levels of bcl/abl mRNA and BCR/ABL fusion protein in the K562/ADM cells and increased apoptosis rate.
Precautions
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Disclaimer
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