Product Name
LINGO-1 (LRRN6A)-S596 (Lingo1), Blocking Peptide
Full Product Name
LINGO-1(LRRN6A)-S596 (C-term) Antibody Blocking Peptide
Product Synonym Names
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A; Lingo1; Lern1; Lrrn6a
Product Gene Name
Lingo1 blocking peptide
[Similar Products]
Product Synonym Gene Name
Lern1; Lrrn6a[Similar Products]
Antibody/Peptide Pairs
LINGO-1 (LRRN6A)-S596 peptide (MBS9225514) is used for blocking the activity of LINGO-1 (LRRN6A)-S596 antibody (MBS9206910)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9D1T0
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Single-pass type I membrane protein
Tissue Location
Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of Lingo1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Lingo1 blocking peptide
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
NCBI/Uniprot data below describe general gene information for Lingo1. It may not necessarily be applicable to this product.
NCBI Accession #
Q9D1T0.1
[Other Products]
UniProt Primary Accession #
Q9D1T0
[Other Products]
UniProt Secondary Accession #
Q3TQJ4; Q6VVF9; Q7TT38[Other Products]
UniProt Related Accession #
Q9D1T0[Other Products]
Molecular Weight
69,101 Da
NCBI Official Full Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
NCBI Official Synonym Full Names
leucine rich repeat and Ig domain containing 1
NCBI Official Symbol
Lingo1??[Similar Products]
NCBI Official Synonym Symbols
LERN1; Lrrn6a; UNQ201; LINGO-1; AV148400; 4930471K13Rik
??[Similar Products]
NCBI Protein Information
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Protein Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Synonym Protein Names
Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
Protein Family
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
UniProt Gene Name
Lingo1??[Similar Products]
UniProt Synonym Gene Names
Lern1; Lrrn6a??[Similar Products]
UniProt Entry Name
LIGO1_MOUSE
UniProt Comments for Lingo1
LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Molecular Function: epidermal growth factor receptor binding; protein binding
Biological Process: axonogenesis; central nervous system neuron development; negative regulation of oligodendrocyte differentiation; neurite development; protein kinase B signaling cascade
Research Articles on Lingo1
1. These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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