Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1; LERN1; LRRN6A; uNQ201

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 90% by SDS-PAGE

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol

1mg/ml (determined by Bradford assay) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of LINGO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Lingo1 also known as Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1. LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1.Recombinant human LINGO1 protein, was expressed in E Coli

Neuroscience

SDS-PAGE

15.1kDa (133aa)

leucine rich repeat and Ig domain containing 1

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

LERN1; LRRN6A??[Similar Products]

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development ().

Mi S., et al (2004). Nat. Neurosci. 7:221-228.; Mi S., et al (2005). Nat. Neurosci. 8:745-751.

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