Product Name
Signal recognition particle 72 kDa protein (SRP72), Recombinant Protein
Popular Item
Full Product Name
Recombinant Human Signal recognition particle 72 kDa protein (SRP72)
Product Gene Name
SRP72 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-671. Full Length of Mature Protein
Sequence
ASGGSGGVSV PALWSEVNRY GQNGDFTRAL KTVNKILQIN KDDVTALHCK VVCLIQNGSF KEALNVINTH TKVLANNSLS FEKAYCEYRL NRIENALKTI ESANQQTDKL KELYGQVLYR LERYDECLAV YRDLVRNSQD DYDEERKTNL SAVVAAQSNW EKVVPENLGL QEGTHELCYN TACALIGQGQ LNQAMKILQK AEDLCRRSLS EDTDGTEEDP QAELAIIHGQ MAYILQLQGR TEEALQLYNQ IIKLKPTDVG LLAVIANNII TINKDQNVFD SKKKVKLTNA EGVEFKLSKK QLQAIEFNKA LLAMYTNQAE QCRKISASLQ SQSPEHLLPV LIQAAQLCRE KQHTKAIELL QEFSDQHPEN AAEIKLTMAQ LKISQGNISK ACLILRSIEE LKHKPGMVSA LVTMYSHEED IDSAIEVFTQ AIQWYQNHQP KSPAHLSLIR EAANFKLKYG RKKEAISDLQ QLWKQNPKDI HTLAQLISAY SLVDPEKAKA LSKHLPSSDS MSLKVDVEAL ENSAGATYIR KKGGKVTGDS QPKEQGQGDL KKKKKKKKGK LPKNYDPKVT PDPERWLPMR ERSYYRGRKK GKKKDQIGKG TQGATAGASS ELDASKTVSS PPTSPRPGSA ATVSASTSNI IPPRHQKPAG APATKKKQQQ KKKKGGKGGW
3D Structure
ModBase 3D Structure for O76094
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SRP72 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SRP72. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001254651.1
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NCBI GenBank Nucleotide #
NM_001267722.1
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UniProt Primary Accession #
O76094
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UniProt Secondary Accession #
Q7Z3C0; G5E9Z8[Other Products]
UniProt Related Accession #
O76094[Other Products]
Molecular Weight
67,879 Da
NCBI Official Full Name
signal recognition particle subunit SRP72 isoform 2
NCBI Official Synonym Full Names
signal recognition particle 72
NCBI Official Symbol
SRP72??[Similar Products]
NCBI Official Synonym Symbols
BMFF; BMFS1; HEL103
??[Similar Products]
NCBI Protein Information
signal recognition particle subunit SRP72
UniProt Protein Name
Signal recognition particle subunit SRP72
UniProt Synonym Protein Names
Signal recognition particle 72 kDa protein
Protein Family
Signal recognition particle
UniProt Gene Name
SRP72??[Similar Products]
UniProt Synonym Gene Names
SRP72??[Similar Products]
NCBI Summary for SRP72
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
UniProt Comments for SRP72
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
Research Articles on SRP72
1. The crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP have been presented.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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