Product Name
Alpha-Melanocyte Stimulating Hormone (aMSH), Antibody Pair Kit
Full Product Name
Alpha-Melanocyte Stimulating Hormone (aMSH) Antibody Pair Kit (with Standard)
Product Synonym Names
alpha-MSH; Intermedins; Alpha-Melanotropin, Alpha-Melanocortin; Alpha-Intermedin
Product Gene Name
aMSH antibody pair kit
[Similar Products]
Matching Pairs
Antibody: Alpha-Melanocyte Stimulating Hormone (aMSH) (MBS2098664)
Pairing: Alpha-Melanocyte Stimulating Hormone (aMSH) (MBS2098664)
Comments: Matched antibody pair kit containing antibody/standard combination
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
Samples
Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids
Detection Range
247-20000pg/mL
Standard
aMSH (Lyophilized, 1 vial-10ug)
Capture Antibody
Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
Detection Antibody
Biotinylated Competitor (Liquid, 1 vial-100mug/500muL)
Producte Usage
Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
Antibody Support Pack
Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090686
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of aMSH antibody pair kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for aMSH antibody pair kit
Tumor immunity; Endocrinology; Hormone metabolism
Applications Tested/Suitable for aMSH antibody pair kit
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
NCBI/Uniprot data below describe general gene information for aMSH. It may not necessarily be applicable to this product.
NCBI Accession #
AAD05037.1
[Other Products]
UniProt Secondary Accession #
Q3MJE7; B5M0B6; D6W5H7[Other Products]
UniProt Related Accession #
O95630[Other Products]
Molecular Weight
39,596 Da
NCBI Official Full Name
AMSH
NCBI Official Synonym Full Names
STAM binding protein
NCBI Official Symbol
STAMBP??[Similar Products]
NCBI Official Synonym Symbols
AMSH; MICCAP
??[Similar Products]
NCBI Protein Information
STAM-binding protein
UniProt Protein Name
STAM-binding protein
UniProt Synonym Protein Names
Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
Protein Family
Amylovoran export outer membrane protein
UniProt Gene Name
STAMBP??[Similar Products]
UniProt Synonym Gene Names
AMSH??[Similar Products]
NCBI Summary for aMSH
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for aMSH
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Research Articles on aMSH
1. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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