Human ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) ELISA kit; ARF1GAP; HRIHFB2281; MGC39924; ADP-ribosylation factor 1 GTPase activating protein; ARF1-directed GTPase-activating protein; GAP protein; ADP-ribosylation factor GTPase activating protein 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ARFGAP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9336072 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ARFGAP1. The ELISA analytical biochemical technique of the MBS9336072 kit is based on ARFGAP1 antibody-ARFGAP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARFGAP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARFGAP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

44,668 Da

ADP-ribosylation factor GTPase activating protein 1

ADP-ribosylation factor GTPase-activating protein 1; ARF1-directed GTPase-activating protein

ADP-ribosylation factor GTPase-activating protein 1

ARF1GAP; ARF GAP 1; ARF1 GAP??[Similar Products]

ARFG1_HUMAN

The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ARF GAP1: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: synapse; cytosol

Molecular Function: protein binding; zinc ion binding; GTPase activator activity

Biological Process: protein transport; COPI coating of Golgi vesicle; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; retrograde vesicle-mediated transport, Golgi to ER; positive regulation of GTPase activity

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