Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Greater than 90% as determined by SDS-PAGE.

20mM Tris-HCl based buffer, pH8.0

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Small volumes of LIGO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.

62.9kD

leucine rich repeat and Ig domain containing 1

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Lern1; Lrrn6a??[Similar Products]

LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9|9 B

Cellular Component: extracellular space; proteinaceous extracellular matrix

Molecular Function: epidermal growth factor receptor binding; protein binding

Biological Process: axonogenesis; central nervous system neuron development; negative regulation of oligodendrocyte differentiation; neurite development; protein kinase B signaling cascade

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