Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

Greater than 90% as determined by SDS-PAGE. (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Lingo1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

As the name states, NOGO negatively regulated neuronal axon growth through oligodendrocytes. LINGO1 - mouse recombinant leucine rich repeat immunoglobulin like domain interacting protein - is a component of the NOGO receptor and therefore tied to signaling pathways, like all receptor interacting proteins. Studies of the basic cell biology functions of LINGO 1 have been hampered without robust antibodies so the availability of a recombinant protein to generate a primary antibody or to use as a positive control will enhance researchers experiments. Creative Biomart - uses multiple expression systems to purify exactly your needs for IP, ELISA or WB assay designs. Besides mouse, we offer other species 1 LINGO1 leucine rich repeat immunoglobulin domain recombinant proteins, all share the same common NOGO receptor interacting domain sequences. Compare our recombinant mouse leucine rich or human leucine rich immunoglobulin domain NOGO to other market suppliers. Our quality is unbeatable and service unparalleled.

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 1 Publication

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

60.8kD

leucine rich repeat and Ig domain containing 1

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Lern1; Lrrn6a??[Similar Products]

LIGO1_MOUSE

LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: epidermal growth factor receptor binding; protein binding

Biological Process: axonogenesis; central nervous system neuron development; negative regulation of oligodendrocyte differentiation; neurite development; protein kinase B signaling cascade

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