Product Name
leucine rich repeat and Ig domain containing 1 (LINGO1), Polyclonal Antibody
Full Product Name
Rabbit anti-human leucine rich repeat and Ig domain containing 1 polyclonal Antibody
Product Synonym Names
leucine rich repeat and Ig domain containing 1; LINGO1; FLJ14594; LERN1; LRRN6A; MGC17422; UNQ201
Product Gene Name
anti-LINGO1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-LINGO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LINGO1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for LINGO1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH11057.2
[Other Products]
UniProt Secondary Accession #
Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80[Other Products]
UniProt Related Accession #
Q96FE5[Other Products]
Molecular Weight
69,146 Da[Similar Products]
NCBI Official Full Name
Leucine rich repeat and Ig domain containing 1
NCBI Official Synonym Full Names
leucine rich repeat and Ig domain containing 1
NCBI Official Symbol
LINGO1??[Similar Products]
NCBI Official Synonym Symbols
LERN1; LRRN6A; UNQ201
??[Similar Products]
NCBI Protein Information
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
UniProt Protein Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Synonym Protein Names
Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
Protein Family
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
UniProt Gene Name
LINGO1??[Similar Products]
UniProt Synonym Gene Names
LERN1; LRRN6A??[Similar Products]
UniProt Entry Name
LIGO1_HUMAN
UniProt Comments for LINGO1
LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: plasma membrane; integral to membrane
Molecular Function: epidermal growth factor receptor binding
Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
Research Articles on LINGO1
1. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
