Full Product Name
FANCL Antibody
Product Synonym Names
FANCL; FAAP43; Fanconi anemia group L protein; PHD finger protein 9; POG; PHF9
Product Gene Name
anti-FANCL antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NW38
Species Reactivity
Human, Mouse, Rat
Specificity
FANCL Antibody detects endogenous levels of total FANCL
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human FANCL
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-FANCL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-FANCL antibody
Total protein Ab
Applications Tested/Suitable for anti-FANCL antibody
Western Blot (WB)
Application Notes for anti-FANCL antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-FANCL antibody
Western blot analysis FANCL using LOVO whole cell lysates
NCBI/Uniprot data below describe general gene information for FANCL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001108108.1
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NCBI GenBank Nucleotide #
NM_001114636.1
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UniProt Primary Accession #
Q9NW38
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UniProt Secondary Accession #
Q6GU60[Other Products]
Molecular Weight
43,430 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase FANCL isoform 1
UniProt Protein Name
E3 ubiquitin-protein ligase FANCL
UniProt Synonym Protein Names
Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
FANCL??[Similar Products]
UniProt Synonym Gene Names
PHF9; FAAP43??[Similar Products]
UniProt Entry Name
FANCL_HUMAN
UniProt Comments for FANCL
FANCL: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Defects in FANCL are the cause of Fanconi anemia complementation group L (FANCL). FANCL is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: nucleoplasm
Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: DNA repair; protein monoubiquitination; response to DNA damage stimulus
Disease: Fanconi Anemia, Complementation Group L; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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