Product Name
Cytochrome P450 4F3 (CYP4F3), Antibody
Full Product Name
Cytochrome P450 4F3 Antibody
Product Gene Name
anti-CYP4F3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q08477
Other Notes
Small volumes of anti-CYP4F3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-CYP4F3 antibody
Western blot analysis Cytochrome P450 4F3 using COLO205 whole cell lysates
NCBI/Uniprot data below describe general gene information for CYP4F3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000887.2
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NCBI GenBank Nucleotide #
NM_000896.2
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UniProt Primary Accession #
Q08477
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UniProt Secondary Accession #
O60634; Q5U740; B7Z8Z3[Other Products]
UniProt Related Accession #
Q08477[Other Products]
Molecular Weight
59,739 Da[Similar Products]
NCBI Official Full Name
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform a
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily F member 3
NCBI Official Symbol
CYP4F3??[Similar Products]
NCBI Official Synonym Symbols
CPF3; CYP4F; LTB4H
??[Similar Products]
NCBI Protein Information
docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Protein Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase
Protein Family
Leukotriene-B(4) omega-hydroxylase
UniProt Gene Name
CYP4F3??[Similar Products]
UniProt Synonym Gene Names
LTB4H; 20-HETE synthase??[Similar Products]
NCBI Summary for CYP4F3
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP4F3
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
Research Articles on CYP4F3
1. The results suggest that a potentially functional single-nucleotide polymorphisms in CYP4F3 (rs4646904) may contribute to the etiology of lung cancer, especially in smokers.
Precautions
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Disclaimer
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