Product Name
Cytochrome P450 4F3 (CYP4F3), Polyclonal Antibody
Popular Item
Full Product Name
Cytochrome P450 4F3 Antibody
Product Synonym Names
CP4F3_HUMAN; CPF3; CYP4F; Cyp4f3; CYPIVF3; Cytochrome P450 4F3; Cytochrome P450 LTB omega; Cytochrome P450, family 4, subfamily F, polypeptide 3; Cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); Cytochrome P450, subfamily IVF, polypeptide 3; Cytochrome P450-LTB-omega; Leukotriene B(4) 20 monooxygenase; Leukotriene B(4) omega hydroxylase; leukotriene B4 omega hydroxylase; Leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-hydroxylase 2; leukotriene-B4 20-monooxygenase; LTB4 omega-hydroxylase; LTB4H
Product Gene Name
anti-CYP4F3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q08477
Specificity
Cytochrome P450 4F3 antibody detects endogenous levels of total Cytochrome P450 4F3
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human Cytochrome P450 4F3
Subcellular Location
Endoplasmic Reticulum Membrane. Microsome Membrane.
Tissue Specificity
Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-CYP4F3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYP4F3 antibody
Function: Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
Similarity: Belongs to the cytochrome P450 family.
Applications Tested/Suitable for anti-CYP4F3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CYP4F3 antibody
WB: 1:1000-3000
Western Blot (WB) of anti-CYP4F3 antibody
Western blot analysis of Cytochrome P450 4F3 using COLO205 whole cell lysates
NCBI/Uniprot data below describe general gene information for CYP4F3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000887.2
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NCBI GenBank Nucleotide #
NM_000896.2
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UniProt Primary Accession #
Q08477
[Other Products]
UniProt Secondary Accession #
O60634; Q5U740; B7Z8Z3[Other Products]
UniProt Related Accession #
Q08477[Other Products]
Molecular Weight
Observed: 60 kDa
Predicted: 60 kDa
NCBI Official Full Name
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform a
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily F member 3
NCBI Official Symbol
CYP4F3??[Similar Products]
NCBI Official Synonym Symbols
CPF3; CYP4F; LTB4H
??[Similar Products]
NCBI Protein Information
docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Protein Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase
Protein Family
Leukotriene-B(4) omega-hydroxylase
UniProt Gene Name
CYP4F3??[Similar Products]
UniProt Synonym Gene Names
LTB4H; 20-HETE synthase1 PublicationManual assertion based on opinion iniRef.10??[Similar Products]
NCBI Summary for CYP4F3
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP4F3
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
Research Articles on CYP4F3
1. High n3:n6 polyunsaturated fatty acids (PUFA) intake was associated with a reduced risk of ulcerative colitis (UC) in individuals with the GG/AG genotype at a single nucleotide polymorphism in CYP4F3 but not those with the AA genotype. The association between dietary n3:n6 PUFA intake and risk of UC may be modified variants at CYP4F3.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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