Human Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2) ELISA kit; RP1-131H7.1; GABA-C receptor; rho-2 subunit; gamma-aminobutyric acid (GABA) receptor; rho 2

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

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Small volumes of GABRR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9330605 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gamma-aminobutyric acid (GABA) receptor, rho 2 (GABRR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GABRR2. The ELISA analytical biochemical technique of the MBS9330605 kit is based on GABRR2 antibody-GABRR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GABRR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GABRR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GABRR2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

54,151 Da

gamma-aminobutyric acid (GABA) A receptor, rho 2

gamma-aminobutyric acid receptor subunit rho-2; GABA-C receptor, rho-2 subunit

Gamma-aminobutyric acid receptor subunit rho-2

GBRR2_HUMAN

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq, Jul 2008]

GABRR2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: protein domain specific binding; chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; visual perception; transport; signal transduction; transmembrane transport; gamma-aminobutyric acid signaling pathway

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