Product Name
Cytochrome P450 4F3 (CYP4F3), Antibody
Full Product Name
Cytochrome P450 4F3 Antibody
Product Gene Name
anti-CYP4F3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q08477
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-CYP4F3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CYP4F3 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CYP4F3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000887.2
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NCBI GenBank Nucleotide #
NM_000896.2
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UniProt Primary Accession #
Q08477
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UniProt Secondary Accession #
O60634; Q5U740; B7Z8Z3[Other Products]
UniProt Related Accession #
Q08477[Other Products]
Molecular Weight
59,739 Da[Similar Products]
NCBI Official Full Name
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform a
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily F member 3
NCBI Official Symbol
CYP4F3??[Similar Products]
NCBI Official Synonym Symbols
CPF3; CYP4F; LTB4H
??[Similar Products]
NCBI Protein Information
docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Protein Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase
Protein Family
Leukotriene-B(4) omega-hydroxylase
UniProt Gene Name
CYP4F3??[Similar Products]
UniProt Synonym Gene Names
LTB4H; 20-HETE synthase??[Similar Products]
NCBI Summary for CYP4F3
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP4F3
CYP4F3: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. Belongs to the cytochrome P450 family.
Protein type: EC 1.14.13.30; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: endoplasmic reticulum membrane
Molecular Function: leukotriene-B4 20-monooxygenase activity; monooxygenase activity; oxygen binding
Biological Process: icosanoid metabolic process; leukotriene metabolic process
Research Articles on CYP4F3
1. Children who consumed a higher dietary ratio of omega6/omega3 were susceptible for Crohn's disease if they were also carriers of specific variants of CYP4F3 and FADS2 genes.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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