Product Name
GLIS3, Polyclonal Antibody
Popular Item
Full Product Name
GLIS3 Antibody
Product Synonym Names
FLJ38999; FLJ90578; GLI similar 3; GLI SIMILAR PROTEIN 3; GLIS family zinc finger 3; MGC33662; OK/KNS-cl.4; Zinc finger protein 515; Zinc finger protein GLIS3; ZNF515
Product Gene Name
anti-GLIS3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NEA6
Specificity
GLIS3 antibody detects endogenous levels of total GLIS3
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human GLIS3
Subcellular Location
Nuclear
Tissue Specificity
In the *****, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.
Predicted Cross Reactivity
Pig, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (80%)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-GLIS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GLIS3 antibody
Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).
Similarity: Belongs to the GLI C2H2-type zinc-finger protein family.
Applications Tested/Suitable for anti-GLIS3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GLIS3 antibody
WB: 1:1000-3000
Western Blot (WB) of anti-GLIS3 antibody
Western blot analysis of GLIS3 using Jurkat whole lysates.
NCBI/Uniprot data below describe general gene information for GLIS3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035878.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001042413.1
[Other Products]
UniProt Primary Accession #
Q8NEA6
[Other Products]
UniProt Secondary Accession #
Q1PHK5; B1AL19[Other Products]
UniProt Related Accession #
Q8NEA6[Other Products]
Molecular Weight
Observed: 84 kDa
Predicted: 84 kDa
NCBI Official Full Name
zinc finger protein GLIS3 isoform a
NCBI Official Synonym Full Names
GLIS family zinc finger 3
NCBI Official Symbol
GLIS3??[Similar Products]
NCBI Official Synonym Symbols
NDH; ZNF515
??[Similar Products]
NCBI Protein Information
zinc finger protein GLIS3
UniProt Protein Name
Zinc finger protein GLIS3
UniProt Synonym Protein Names
GLI-similar 3; Zinc finger protein 515
Protein Family
Zinc finger protein
UniProt Gene Name
GLIS3??[Similar Products]
UniProt Synonym Gene Names
ZNF515??[Similar Products]
NCBI Summary for GLIS3
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for GLIS3
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' ().
Research Articles on GLIS3
1. Data did not show any associations of GLI similar 3 protein (GLIS3) gene polymorphisms rs806052, rs143051164, and rs149840771 with carbohydrate metabolism disorders among patients with maturity onset diabetes of the young (MODY) and type 2 diabetes mellitus (DM2) in Russia.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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