Product Name
GLIS3, cDNA Clone
Full Product Name
GLIS3 cDNA Clone
Product Gene Name
GLIS3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgatggttc agcgactggg actcatttca cctccagcaa gccaggtctc tacagcatgc aaccagatca gtcctagctt acagagggca atgaatgcag ccaacctgaa tatacctcct tcagatacca ggtcccttat ttcgcgtgag tctttggcgt ccacgacctt gagtctgacg gaaagtcagt cggcctcaag catgaagcag gagtggtccc agggctacag ggccctccct tcgctctcca accacggctc tcagaatggc cttgatctag gggatctcct tagccttcct cccgggacat ccatgtccag caatagtgtc tctaactcat taccatccta cctttttggc acggaaagta gccactctcc ttaccctagt cctcggcact catccaccag gtcccactcg gcccgctcca agaagagagc gctgtccttg tccccgctgt ccgatggcat cgggatagat ttcaatacca tcatccgcac gtcgcccacg tccttggtgg cctacatcaa cgggtcgagg gcttcgccgg ccaacctgtc cccgcagccg gaggtctacg ggcatttcct gggcgtgcgc ggcagctgca ttccccagcc gcgcccggtg cccggcagcc agaagggcgt gctggtggcc cctggaggcc tggcgctgcc ggcctacggc gaggacgggg ccctggagca cgagcgcatg caacagctgg agcacggcgg cctgcagcca ggcctggtca accacatggt ggtgcagcat ggcctgccgg gccccgacag ccagccggcc ggcctgttca agaccgaacg cctggaggag ttcccgggca gcaccgtaga cctacccccc gcgcctccgc tccctcctct gccgccgccc caaggccccc caccccctta ccatgcccat gcgcaccttc accacccgga gctcgggccc cacgcccagc agctggcctt gccccaggcc accctggacg acgacgggga gatggacggc atcgggggca agcattgcta ccgctggatc gactgcagcg ccctgtacga ccagcaggag gagctcgtgc ggcacatcga gaaggtccac atcgaccagc gcaaagggga ggacttcact tgcttctggg ccggttgccc tcgaagatac aagcccttca acgcccgcta taaactgctg atccacatga gagtccactc tggggagaag cccaacaagt gtacgtttga aggttgcgag aaggcctttt caaggcttga aaatctcaag atccacttgc ggagccacac aggcgagaag ccgtatttgt gccagcatcc gggttgtcag aaggccttca gtaactccag tgaccgcgcc aaacaccagc ggacgcatct ggacaccaaa ccttatgctt gtcaaattcc aggatgtacc aaacgctaca cagacccaag ttccctaaga aagcatgtga aggcacattc ttccaaagag caacaagcaa ggaaaaagtt gcggtccagc acagagctcc atccagacct gctcacagat tgcctcaccg tgcagtccct gcagccggcc acttccccta gagatgctgc tgctgaaggg accgtgggac gctcccctgg acccgggcct gacctctatt cagctcccat tttctccagc aattattcaa gccgaagtgg aacagctgct ggggccgtac cacccccaca tcctgtcagt cacccttctc caggacataa tgtacagggg agccctcaca acccctcctc ccagttacct ccactcacag ctgtggacgc aggagctgag aggtttgcac cttctgctcc atctcctcac cacatcagcc cccggagagt tccagctcct tcttcaatac tgcaaagaac acagcctccc tatacccagc agccatcagg ttcacacctg aagtcctatc agccagaaac aaactcttct tttcaaccaa atggtatcca tgtccatgga ttttatgggc agctgcagaa gttctgtccc ccacactacc ccgattccca gagaattgtg ccgcctgtca gctcctgcag tgtggtgcct tcgtttgagg actgcctagt ccctacatcc atgggccagg ccagttttga tgttttccac agagccttct cgactcactc gggcattaca gtgtatgatt taccttcaag ttcctcgagc ctctttgggg agtctctccg cagcggggct gaagatgcta ccttcttgca gatcagcacc gtggaccgct gtcctagcca gctctcctct gtctacaccg aaggctaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GLIS3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GLIS3. It may not necessarily be applicable to this product.
NCBI Accession #
BC033899
[Other Products]
UniProt Secondary Accession #
Q1PHK5; B1AL19[Other Products]
UniProt Related Accession #
Q8NEA6[Other Products]
Molecular Weight
99,605 Da
NCBI Official Full Name
Homo sapiens GLIS family zinc finger 3, mRNA
NCBI Official Synonym Full Names
GLIS family zinc finger 3
NCBI Official Symbol
GLIS3??[Similar Products]
NCBI Official Synonym Symbols
NDH; ZNF515
??[Similar Products]
NCBI Protein Information
zinc finger protein GLIS3
UniProt Protein Name
Zinc finger protein GLIS3
UniProt Synonym Protein Names
GLI-similar 3; Zinc finger protein 515
Protein Family
Zinc finger protein
UniProt Gene Name
GLIS3??[Similar Products]
UniProt Synonym Gene Names
ZNF515??[Similar Products]
UniProt Entry Name
GLIS3_HUMAN
NCBI Summary for GLIS3
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for GLIS3
GLIS3: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. Defects in GLIS3 are a cause of diabetes mellitus neonatal with congenital hypothyroidism (NDH). NDH is a neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: Golgi apparatus; nucleoplasm; nucleus
Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
Research Articles on GLIS3
1. It may play a role in a number of physiological processes controlled by Glis3.
Precautions
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Disclaimer
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