Full Product Name
GLIS3 Antibody, HRP Conjugated
Product Synonym Names
Zinc finger protein GLIS3; GLI-similar 3; Zinc finger protein 515; GLIS3; ZNF515
Product Gene Name
anti-GLIS3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NEA6
Purity/Purification
>95%
Protein G Purified
Immunogen
Recombinant Human Zinc finger protein GLIS3 protein (527-663AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GLIS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-GLIS3 antibody
Epigenetics and Nuclear Signaling
Applications Tested/Suitable for anti-GLIS3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for GLIS3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035878.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001042413.2
[Other Products]
UniProt Primary Accession #
Q8NEA6
[Other Products]
UniProt Secondary Accession #
Q1PHK5; B1AL19[Other Products]
UniProt Related Accession #
Q8NEA6[Other Products]
Molecular Weight
99,605 Da
NCBI Official Full Name
zinc finger protein GLIS3 isoform a
NCBI Official Synonym Full Names
GLIS family zinc finger 3
NCBI Official Symbol
GLIS3??[Similar Products]
NCBI Official Synonym Symbols
NDH; ZNF515
??[Similar Products]
NCBI Protein Information
zinc finger protein GLIS3
UniProt Protein Name
Zinc finger protein GLIS3
UniProt Synonym Protein Names
GLI-similar 3; Zinc finger protein 515
Protein Family
Zinc finger protein
UniProt Gene Name
GLIS3??[Similar Products]
UniProt Synonym Gene Names
ZNF515??[Similar Products]
NCBI Summary for GLIS3
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for GLIS3
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' ().
Research Articles on GLIS3
1. Data show that loss of zinc finger protein GLIS3 (GLIS3) causes beta-cell death.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
