Full Product Name
GLIS3 Antibody
Product Gene Name
anti-GLIS3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NEA6
Other Notes
Small volumes of anti-GLIS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-GLIS3 antibody
Western blot analysis GLIS3 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for GLIS3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035878.1
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NCBI GenBank Nucleotide #
NM_001042413.1
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UniProt Primary Accession #
Q8NEA6
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UniProt Secondary Accession #
Q1PHK5; B1AL19[Other Products]
UniProt Related Accession #
Q8NEA6[Other Products]
Molecular Weight
99,605 Da
NCBI Official Full Name
zinc finger protein GLIS3 isoform a
NCBI Official Synonym Full Names
GLIS family zinc finger 3
NCBI Official Symbol
GLIS3??[Similar Products]
NCBI Official Synonym Symbols
NDH; ZNF515
??[Similar Products]
NCBI Protein Information
zinc finger protein GLIS3
UniProt Protein Name
Zinc finger protein GLIS3
UniProt Synonym Protein Names
GLI-similar 3; Zinc finger protein 515
Protein Family
Zinc finger protein
UniProt Gene Name
GLIS3??[Similar Products]
UniProt Synonym Gene Names
ZNF515??[Similar Products]
NCBI Summary for GLIS3
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for GLIS3
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' ().
Research Articles on GLIS3
1. Replication of lead type 2 diabetes mellitus SNPs in GLIS3, KCNK16, and ZFAND3 was observed in American Indians. Sex-specific T2DM signals in GLIS3 and ZFAND3, which are distinct from the East Asian GWAS signals, were also identified.
Precautions
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Disclaimer
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