Full Product Name
MLL2 Antibody
Product Gene Name
anti-MLL2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14686
Other Notes
Small volumes of anti-MLL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-MLL2 antibody
Western blot analysis MLL2 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for MLL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003473.3
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NCBI GenBank Nucleotide #
NM_003482.3
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UniProt Primary Accession #
O14686
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UniProt Secondary Accession #
O14687[Other Products]
UniProt Related Accession #
O14686[Other Products]
Molecular Weight
593,677 Da
NCBI Official Full Name
histone-lysine N-methyltransferase 2D
NCBI Official Synonym Full Names
lysine methyltransferase 2D
NCBI Official Symbol
KMT2D??[Similar Products]
NCBI Official Synonym Symbols
ALR; KMS; MLL2; MLL4; AAD10; KABUK1; TNRC21; CAGL114
??[Similar Products]
NCBI Protein Information
histone-lysine N-methyltransferase 2D
UniProt Protein Name
Histone-lysine N-methyltransferase 2D
UniProt Synonym Protein Names
ALL1-related protein; Myeloid/lymphoid or mixed-lineage leukemia protein 2
UniProt Gene Name
KMT2D??[Similar Products]
UniProt Synonym Gene Names
ALR; MLL2; MLL4; Lysine N-methyltransferase 2D??[Similar Products]
NCBI Summary for MLL2
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]
UniProt Comments for MLL2
Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
Research Articles on MLL2
1. analysis of highly recurrent genetic lesions in components of the NF-kappaB pathway, of NOTCH1 and NOTCH2 as well as KMT2D that may have a role in ocular adnexal MALT-type marginal zone lymphomas
Precautions
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Disclaimer
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