Product Name
GLRA1/Glycine Receptor Alpha 1, Polyclonal Antibody
Full Product Name
Anti-GLRA1/Glycine Receptor Alpha 1 Antibody (N-Terminus)
Product Synonym Names
Goat Polyclonal to Rat GLRA1/Glycine Receptor Alpha 1; GLRA1; Alpha 1 glycine Receptor; GlyR alpha 1; GLYRA1; SPD; STHE; Spasmodic; Glycine receptor alpha 1; Glycine receptor; alpha 1; HKPX1; Strychnine binding subunit
Product Gene Name
anti-GLRA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23415
Species Reactivity
Human
Predicted: Mouse
Specificity
Endogenous levels of mouse alpha 1 Glycine Receptor. It is predicted to react with human alpha 1 Glycine Receptor according to sequence homology. Positive Control: Mouse brain.
Purity/Purification
Immunoaffinity Purified
Form/Format
Lyophilized from PBS, pH 7.4, 0.02% sodium azide.
Immunogen
KLH-coupled synthetic peptide from N-terminal of human alpha 1 Glycine Receptor (Swiss Prot: P23415)
Resuspension Liquid
Distilled water
Preparation and Storage
Store lyophilized at -20 degree C.
The reconstituted product can be stored for short term at 4 degree C or long term at -20 degree C or below.
Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-GLRA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GLRA1 antibody
important inhibitory transmitter in the brainstem and spinal cord.Glycine receptors are members of the ligand-gated ion channel family(LGICs) that mediate rapid chemical neurotransmission. the binding ofglycine to its receptor produces a large increase in chlorideconductance, which causes membrane hyperpolarization. Glycine receptorsare anchored at inhibitory chemical synapses by a cytoplasmic protein , gephyrin.
Product Categories/Family for anti-GLRA1 antibody
Ion Channel; Glycine receptor
Applications Tested/Suitable for anti-GLRA1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-GLRA1 antibody
IHC-P: 10 ug/ml
WB: 1-2 ug/ml
Immunohistochemistry (IHC) of anti-GLRA1 antibody
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry (WB) of anti-GLRA1 antibody
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western Blot (WB) of anti-GLRA1 antibody
Western blot analysis of tissue lysates using alpha 1 Glycine Receptor Antibody, pAb, Rabbit.
NCBI/Uniprot data below describe general gene information for GLRA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000162.2
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NCBI GenBank Nucleotide #
NM_000171.3
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UniProt Primary Accession #
P23415
[Other Products]
UniProt Secondary Accession #
Q14C77; Q6DJV9; B2R6T3[Other Products]
UniProt Related Accession #
P23415[Other Products]
Molecular Weight
51,693 Da
NCBI Official Full Name
glycine receptor subunit alpha-1 isoform 2
NCBI Official Synonym Full Names
glycine receptor alpha 1
NCBI Official Symbol
GLRA1??[Similar Products]
NCBI Official Synonym Symbols
STHE; HKPX1
??[Similar Products]
NCBI Protein Information
glycine receptor subunit alpha-1
UniProt Protein Name
Glycine receptor subunit alpha-1
UniProt Synonym Protein Names
Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit
Protein Family
Glycine receptor
UniProt Gene Name
GLRA1??[Similar Products]
NCBI Summary for GLRA1
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]
UniProt Comments for GLRA1
Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol ().
Research Articles on GLRA1
1. Results support the notion that the efficacies of ligands for the alpha1 GlyR are determined by conformational changes that occur within and near the ligand-binding domain: disruption of the D97-R119 interaction may be an important element in receptor activation and that agonists may break this putative intersubunit bond in order to destabilize the initial shut state and facilitate transitions towards the open state.
Precautions
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