Product Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence c (CBLC), Polyclonal Antibody
Full Product Name
Rabbit anti-human Cas-Br-M (murine) ecotropic retroviral transforming sequence c polyclonal Antibody
Product Synonym Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence c; CBLC; CBL-3; CBL-SL; RNF57
Product Gene Name
anti-CBLC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8372 / sc-8371
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CBLC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CBLC antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CBLC. It may not necessarily be applicable to this product.
NCBI Accession #
EAW57293.1
[Other Products]
UniProt Secondary Accession #
Q8N1E5; Q9Y5Z2; Q9Y5Z3[Other Products]
UniProt Related Accession #
Q9ULV8[Other Products]
Molecular Weight
47,418 Da[Similar Products]
NCBI Official Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence c, isoform CRA_b
NCBI Official Synonym Full Names
Cbl proto-oncogene C, E3 ubiquitin protein ligase
NCBI Official Symbol
CBLC??[Similar Products]
NCBI Official Synonym Symbols
CBL-3; RNF57; CBL-SL
??[Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; signal transduction protein CBL-C; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c
UniProt Protein Name
E3 ubiquitin-protein ligase CBL-C
UniProt Synonym Protein Names
RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
CBLC??[Similar Products]
UniProt Synonym Gene Names
CBL3; RNF57??[Similar Products]
UniProt Entry Name
CBLC_HUMAN
NCBI Summary for CBLC
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for CBLC
Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleus
Molecular Function: signal transducer activity; phosphotyrosine binding; zinc ion binding; calcium ion binding; SH3 domain binding; ligase activity; epidermal growth factor receptor binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination
Research Articles on CBLC
1. The ubiquitin ligase activity of Cbl-c by the direct interaction of the LIM zinc coordinating domain of Hic5 is demonstrated.
Precautions
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Disclaimer
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