Human Signal transduction protein CBL-C (CBLC) ELISA kit; CBL-3; CBL-SL; RNF57; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of CBLC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328507 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cas-Br-M (murine) ecotropic retroviral transforming sequence c (CBLC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CBLC. The ELISA analytical biochemical technique of the MBS9328507 kit is based on CBLC antibody-CBLC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CBLC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CBLC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

52,456 Da

Cbl proto-oncogene C, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; signal transduction protein CBL-C; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c

E3 ubiquitin-protein ligase CBL-C

CBL3; RNF57??[Similar Products]

CBLC_HUMAN

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleus

Molecular Function: signal transducer activity; phosphotyrosine binding; zinc ion binding; calcium ion binding; SH3 domain binding; epidermal growth factor receptor binding; ligase activity

Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination

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