Full Product Name
EHD2 Antibody, HRP conjugated
Product Synonym Names
EH domain-containing protein 2Curated; PAST homolog 2Curated; EHD2
Product Gene Name
anti-EHD2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NZN4
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human EH domain-containing protein 2 protein (401-543AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-70263 / sc-70264 / sc-70266
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-EHD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EHD2 antibody
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed: 17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity).
Applications Tested/Suitable for anti-EHD2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for EHD2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055416.2
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NCBI GenBank Nucleotide #
NM_014601.3
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UniProt Primary Accession #
Q9NZN4
[Other Products]
UniProt Secondary Accession #
Q96CB6; B2RDH9; B4DNU6[Other Products]
UniProt Related Accession #
Q9NZN4[Other Products]
Molecular Weight
46,059 Da
NCBI Official Full Name
EH domain-containing protein 2
NCBI Official Synonym Full Names
EH domain containing 2
NCBI Official Symbol
EHD2??[Similar Products]
NCBI Official Synonym Symbols
PAST2
??[Similar Products]
NCBI Protein Information
EH domain-containing protein 2
UniProt Protein Name
EH domain-containing protein 2
UniProt Synonym Protein Names
PAST homolog 2Curated
Protein Family
EH domain-containing protein
UniProt Gene Name
EHD2??[Similar Products]
UniProt Entry Name
EHD2_HUMAN
NCBI Summary for EHD2
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]
UniProt Comments for EHD2
EHD2: Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: caveola; cytosol; endosome membrane; extrinsic to membrane; nucleus; plasma membrane; recycling endosome membrane
Molecular Function: nucleic acid binding; protein binding
Biological Process: blood coagulation; endocytic recycling
Research Articles on EHD2
1. Data suggest that the EH-domain containing 2 protein (EHD2) NPF phenylalanine residue is crucial for EHD2 localization to the plasma membrane, whereas the proline residue is essential for EHD2 dimerization and binding.
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