Full Product Name
Mouse Monoclonal Antibody to KDM6A
Product Synonym Names
UTX; KABUK2; bA386N14.2
Product Gene Name
anti-KDM6A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Other Notes
Small volumes of anti-KDM6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KDM6A antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-KDM6A antibody
Western blot using Recombinant protein
Western blot using Transfection expressed protein
NCBI/Uniprot data below describe general gene information for KDM6A. It may not necessarily be applicable to this product.
NCBI Accession #
JAO55486.1
[Other Products]
UniProt Secondary Accession #
Q52LL9; Q5JVQ7[Other Products]
UniProt Related Accession #
O15550[Other Products]
NCBI Official Full Name
KDM6A
NCBI Official Synonym Full Names
lysine demethylase 6A
NCBI Official Symbol
KDM6A??[Similar Products]
NCBI Official Synonym Symbols
UTX; KABUK2; bA386N14.2
??[Similar Products]
NCBI Protein Information
lysine-specific demethylase 6A
UniProt Protein Name
Lysine-specific demethylase 6A
UniProt Synonym Protein Names
Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
Protein Family
Lysine-specific demethylase
UniProt Gene Name
KDM6A??[Similar Products]
UniProt Synonym Gene Names
UTX??[Similar Products]
NCBI Summary for KDM6A
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
UniProt Comments for KDM6A
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression ().
Research Articles on KDM6A
1. both UTX and UTY function as dose-dependent suppressors of urothelial bladder cancer development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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